Application of mesenchymal stem cells in cellula therapy of wounds

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 386

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شناسه ملی سند علمی:

ITERMED01_303

تاریخ نمایه سازی: 7 مرداد 1398

چکیده مقاله:

Cell therapy, with mesenchymal stem cells (MSCs), shows remarkable potential to treat various types of diabetic foot ulcers, burn wound, wrinkles and scars. To prepare MSCs for clinical application, some critical points must be taken into consideration: isolation and culture of these cells to produce a homogeneous population of non-contaminated cells, a method for rapid growth, and development of a proportional number of MSCs with proper strength and viability. In addition, an appropriate site for a biopsy should be selected based on indications of treatment and maintenance. Ultimately, the clinical use of MSCs in wound healing obviates the need for ready to use reservoir of these cells. In this regard, tissue allografts can be used in both fresh and frozen forms. The fresh type is more desirable due to its high chance of survival. Developing the appropriate preservation methods for allogeneic MSCs is the emerging research field of interest. Furthermore, applying biomaterials will increase the efficacy of MSCs in wound healing. Skin diseases around the world rise with the increase in accidents, changes in people’s lifestyle habits, and other diseases that affect the skin. Therefore, treatment with MSCs cells, in an appropriate biomaterial matrix, can improve their efficacy. These cells can actively affect the same cells or neighbor cells when exposed to any environment by specific secretion and expression of their differentiating markers. Extensive research on the proper function of these cells for treatment of ulcers, diabetic ulcer, skin wrinkles, and burns have proven to be promising. Therefore, cell therapy, based on MSSs, provides good treatment for skin regeneration.

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نویسندگان

Sona Zare

Department of Biology, Faculty of Basic Science, Islamic Azad University, Hamedan Branch, Hamedan, Iran

Mohammad Ali Nilforoushzadeh

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Rahim Ahmadi

Department of Biology, Faculty of Basic Science, Islamic Azad University, Hamedan Branch, Hamedan, Iran

Abdolreza Mohamadnia

Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), ShahidBeheshti University ofMedical Sciences, Tehran, Iran.