Self-assembling peptide nanofiber as a bioinspired hydrogel induces bone and nerve repair
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 282
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
ITERMED01_401
تاریخ نمایه سازی: 7 مرداد 1398
چکیده مقاله:
Despite the many advances in tissue engineering associated with spinal fractures and spinal cord injuries, both of them yet challenging and controversial in clinics. The high prevalence of spinal fractures and spinal cord injuries, necessitates more attention to restorative and repair fractures and injuries. Meantime, a hydrogel-based scaffolds that fill completely cavities and defect sites and they are favorable integrated throughout the defects are promising and preferable to calcium-phosphate materials such as hydroxyapatite and tricalcium phosphate due to their gelling form and cell encapsulation potential. However, one of the most important properties of a hydrogel-based scaffolds is mimicking of physiological milieu that favorably encapsulate cells and form a 3D extracellular matrix with high pore interconnectivity. It seems that self-assembling peptide nanofiber is a good candidate that covers the most requirements of a spinal ans spinal cord scaffold. It is notable that self-assembling peptide nanofiber that are containing special biological motifs will repair spine fractures and spinal core injuries, as well. Our studies showed that self-f-assembling peptide nanofibers are biocompatible and favorably are integrated into the defects sites. It is worth nothing that implantation of the self-assembling peptide nanofiber in spine not only will repair spine but also, its degradation will stimulate motor neuron recovery and myelination of injured spinal cord under the spine
کلیدواژه ها:
نویسندگان
Shima Tavakol
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
Behnaz Tavakol
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Bita Rasoulian
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
Seyed Mahdi Rezayat
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.