Tissue engineering approaches in diagnosis and treatment of neurological diseases

Tissue engineering approaches will help characterization and clarification of neuropathogenic processes, create and apply innovative technologies for advanced neuroscience research, and develop novel methods and strategies to create new ways for improving the lives of patients with neurological disorders. Emerging microelectronic technologies is going to use for development of human noninvasive, high-density, multimodal, mobile brain/body imaging and analyses, and implantable applications of closed-loop systems. Tissue engineering approaches could improve these microelectronic technologies to more safe and long term usage in patient body. For example, responsive nerve stimulation or RNS is a new tool for rapid detection of seizure by sensing electrical activity of brain, as well as the application of an electrical stimulation that suppresses seizures. The most important issue in the application of such tools is to increase the time of their performance within the brain tissue with the least degree of destruction to the tissue. This tool has two important parts or leads, one that receives brain waves, and one that transmits external stimulation to the brain. The use of decellularized membranes as electrodes sheet in these two parts is a very promising approach to long-term use of this device. So such approaches will facilitate diagnosis, monitoring of treatment efficacy, and prediction of outcome for neurological diseases such as seizure and Parkinson’s disease

کلیدواژه ها:

Tissue engineering ، Neurological diseases.