Evaluation of acute and sub-acute toxicity of Pinus eldarica bark extract in Wistar rats

سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 417

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شناسه ملی سند علمی:

JR_AJP-6-5_010

تاریخ نمایه سازی: 1 مهر 1398

چکیده مقاله:

Objective: Pinus eldarica (P. eldarica) is one of the most common pines in Iran which has various bioactive constituents and different uses in traditional medicine. Since there is no documented evidence for P. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of P. eldarica bark were investigated in male and female Wistar rats in this study. Materials and Methods: In the acute study, a single dose of extract (2000 mg/kg) was orally administered and animals were monitored for 7 days. In the sub-acute study, repeated doses (125, 250 and 500 mg/kg/day) of the extract were administered for 28 days and biochemical, hematological and histopathological parameters were evaluated. Results: Our results showed no sign of toxicity and no mortality after single or repeated administration of P. eldarica. The median lethal dose (LD50) of P. eldarica was determined to be higher than 2000 mg/kg. The mean body weight and most of the biochemical and hematological parameters showed normal levels.  There were only significant decreases in serum triglyceride levels at the doses of 250 and 500 mg/kg of the extract in male rats (pConclusion: Oral administration of the hydroalcoholic extract of P. eldarica bark may be considered as relatively non-toxic particularly at the doses of 125 and 250 mg/kg.

نویسندگان

Akram Ghadirkhomi

Department of Pharmacology, Islamic Azad University, Shahreza Branch, Shahreza, Iran

Leila Safaeian

Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Behzad Zolfaghari

Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Reza Aghaye-Ghazvini

Isfahan Center of Public Health Training and Research, Institute of Public Health Research, Tehran University of Medical Science, Iran

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  • Afsharypour S, Sanaty F. 2005. Essential oil constituents of leaves ...
  • Aschwanden C. 2001. Herbs for health, but how safe are ...
  • Arsad SS, Esa NM, Hamzah H. 2014. Histopathologic changes in ...
  • Bolandghamat S, Moghimi A, Iranshahi M. 2011. Effects of ethanolic ...
  • But PPH, Tai YT, Young K. 1994. Three fatal cases ...
  • Chan W, Lee KC, Liu N, Cai ZW. 2007. A ...
  • Fallahhuseini H, Mehrzadi S, Ghaznavi H, Tajallizadehkhoob Y, Fakhrzadeh H. ...
  • Farah-Amna O, Nooraain H, Noriham A, Azizah AH, Nurul-Husna R. ...
  • Farjon A. 2005. Pines: drawings and description of the genus ...
  • Gulati OP. 2005. The nutraceutical Pycnogenol: its role in cardiovascular ...
  • Hansson P, Saggerson D, Nilsson-Ehle P. 1991. Sex difference in ...
  • Hosseinzadeh H, Khooei A, Khashayarmanesh Z, Motamed-Shariaty V. 2010. Antiurolithiatic ...
  • Huseini HF, Anvari MS, Khoob YT, Rabbani S, Sharifi F, ...
  • Ko R. 1999. Adverse reactions to watch for in patients ...
  • Mamedov N, Craker LE. 2001. Medicinal plants used for the ...
  • Mamedov N, Gardner Z, Craker LE. 2005. Medicinal plants used ...
  • McLean EK. 1970. The toxic actions of pyrrolizidine (Senecio) alkaloids. ...
  • Mullins RJ. 1998. Echinacea-associated anaphylaxis. Med J Aust, 168: 170-171. ...
  • Neergheen-Bhujun VS. 2013. Underestimating the toxicological challenges associated with the ...
  • Nortier JL, Martinez MC, Schmeiser HH, Arlt VM, Bieler CA, ...
  • Ogbonnia S, Adekunle AA, Bosa MK, Enwuru VN. 2008. Evaluation ...
  • Ogbonnia SO, Olayemi SO, Anyika EN, Enwuru VN, Poluyi OO. ...
  • Organisation for Economic Cooperation and Development (OECD). 2002. Guidelines for ...
  • Organisation for Economic Cooperation and Development (OECD). 2000. Guidance Document ...
  • Organisation for Economic Cooperation and Development (OECD). 2008. Guidelines for ...
  • Testing of Chemicals No. 407, Repeated dose oral toxicity test ...
  • The Globally Harmonized System (GHS) of Classification and Labelling of ...
  • World Health Organization (WHO). 2008. Traditional Medicine Fact sheet No. ...
  • Yen GC, Duh PD, Huang DW, Hsu CL, Fu TY. ...
  • Yoo KM, Lee CH, Lee H, Moon B, Lee CY. ...
  • Zolfaghari B, Iravani S. 2012. Essential oil constituents of the ...
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