Protective effects of hydro-alcoholic extract of Quercus brantii against lead-induced oxidative stress in the reproductive system of male mice

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 380

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

این مقاله در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_AJP-8-5_007

تاریخ نمایه سازی: 18 تیر 1398

چکیده مقاله:

Objective: Exposure to heavy metals such as lead (Pb) results in oxidative stress induction in the male reproductive system. Herbal medicine can be utilized as antioxidant agents against oxidative stress. Quercus brantii (QB) has shown antioxidant activity in previous studies. The aim of the present study was to evaluate effects of QB hydro-alcoholic extract against Pb-induced oxidative stress in the male mice reproductive system. Materials and Methods: Forty-two NMRI adult male mice were randomly divided into 7 groups of 6 animals each. Group I was the control group that received no treatment. Group II was the sham group and received 0.2 ml distilled water. Groups III and IV received QB hydro-alcoholic extract 500 and 1000 mg/kg bw, respectively. Group V received Pb 1000 ppm/kg bw. Group VI and VII received Pb 1000 ppm/kg bw and QB extract 500 and 1000 mg/kg bw, respectively. All groups received treatment via oral gavage. After 35 days, sperm parameters (i.e. sperm motility, count and morphology) were evaluated. Levels of sex hormones including LH, FSH, and testosterone, total antioxidant capacity (TAC), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured in animals’ serum.  Results: Exposure to Pb negatively affected sperm parameters (i.e. sperm motility, count and morphology), decreased serum concentrations of sex hormones (i.e. LH, FSH, and testosterone), TAC and SOD activity but increased MDA levels. However, co-administration of 500 and 1000 mg/kg bw QB hydro-alcoholic extract and Pb considerably improved sperm parameters (i.e. sperm motility, count and morphology), increased sex hormones (i.e.LH, FSH, and testosterone), TAC, and SOD activity while decreased MDA levels in animals’ serum. Conclusion: Administration of QB extracts (Low dose and high dose) is able to protect the male reproductive system of mice against Pb-induced oxidative stress.

نویسندگان

Ali Soleimanzadeh

Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Mehdi Kian

Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Sajjad Moradi

Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Farin Malekifard

Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Agarwal A, Virk G, Ong C, du Plessis SS. 2014. ...
  • Hamadouche NA, NESRINE S, ABDELKEDER A. 2013. Lead toxicity and ...
  • Aitken RJ. 1995. Free radicals, lipid peroxidation and sperm function. ...
  • Aitken RJ, Roman SD. 2008. Antioxidant systems and oxidative stress ...
  • Al-Omair MA, Sedky A, Ali A, Elsawy H. 2017. Ameliorative ...
  • Amin, GR. 1991. Popular medicinal plants of Iran, Vol. 1, ...
  • Anjum MR, Madhu P, Reddy KP, Reddy PS. 2017. The ...
  • njum, M. R., Sainath, S. B., Suneetha, Y., & Reddy, ...
  • Ayinde OC, Ogunnowo S, Ogedegbe RA. 2012. Influence of Vitamin ...
  • Azizi S, Pirbalouti AG, Amirmohammadi M. 2014. Effect of hydro-alcoholic ...
  • Bajalan I, Javadian M, Zarinkoob S, Dalvand H. 2014. Antibacterial ...
  • Benzie IF, Strain JJ. 1999. [2] Ferric reducing/antioxidant power assay: ...
  • Chowdhury AR. 2009. Recent advances in heavy metals induced effect ...
  • Çoruh N, Nebigil C, Özgökce F. 2014. Rapid and comprehensive ...
  • Creasy DM. 2001. Pathogenesis of male reproductive toxicity. Toxicol Pathol, ...
  • Dogan A, Celik I, Kaya MS. 2015. Antidiabetic properties of ...
  • Dorostghoal M, Seyyednejad SM, Jabari A. 2014. Protective effects of ...
  • El-Nekeety AA, El-Kady AA, Soliman MS, Hassan NS, Abdel-Wahhab MA. ...
  • Elgawish RA, Abdelrazek HM. 2014. Effects of lead acetate on ...
  • Fernandez CD, Bellentani FF, Fernandes GS, Perobelli JE, Favareto AP, ...
  • Gandhi J, Hernandez RJ, Chen A, Smith NL, Sheynkin YR, ...
  • Kakkar P, Jaffery FN. Biological markers for metal toxicity. 2005. ...
  • Karimi A, Rafieian-Kopaei M, Moradi MT, Alidadi S. 2016. Anti–Herpes ...
  • Kemprinas W, Melo V, Santos A. 1990. Saturnism in male ...
  • Kianoush S, Sadeghi M, Balali-Mood M. 2015. Recent Advances in ...
  • Loraine JA, Bell ET. 1971. Hormone assays and their clinical application (No. ...
  • Mabrouk A, Ben Cheikh H. 2016. Thymoquinone supplementation ameliorates lead-induced ...
  • Malecka A, Piechalak A, Tomaszewska B. 2009. Reactive oxygen species ...
  • Mangoli E, Talebi AR, Anvari M, Pourentezari M. 2013. Effects ...
  • Mohammadi J, Nikbakht J, Mohammadi B, Jafari Barmak M, Vafaienejad ...
  • Mohammadzadeh A, Samadi-Maybodi A, Khodadoust S. 2013. Determination of trace ...
  • Moradi MT, Karimi A, Alidadi S, Ghasemi-Dehkordi P, Ghaffari-Goosheh MS. ...
  • Moradi MT, Karimi A, Alidadi S. 2016b. In vitro antiproliferative ...
  • Naik GH, Priyadarsini KI, Satav JG, Banavalikar MM, Sohoni DP, ...
  • Niki E. 2008. Lipid peroxidation products as oxidative stress biomarkers. ...
  • Nishikimi M, Rao NA, Yagi K. 1972. The occurrence of ...
  • Packer L, Weber SU, Rimbach G. 2001. Molecular aspects of ...
  • Pandya C, Pillai P, Nampoothiri LP, Bhatt N, Gupta S. ...
  • Patra RC, Rautray AK, Swarup D. 2011. Oxidative stress in ...
  • Placer ZA, Cushman LL, Johnson BC. 1966. Estimation of product ...
  • Karimi A, Moradi MT, Saeedi M, Asgari S, Rafieian-Kopaei M. ...
  • Safary A, Motamedi H, Maleki S, Seyyednejad SM. 2009. A ...
  • Sainath SB, Meena R, Supriya C, Reddy KP, Reddy PS. ...
  • El Shafai A, Zohdy N, El Mulla K, Hassan M, ...
  • Sharma V, Kansal L, Sharma A. 2010. Prophylactic efficacy of ...
  • Tahmouzi S. 2014. Optimization of polysaccharides from Zagros oak leaf ...
  • Thoreux-Manlay A, Le Goascogne C, Segretain D, Jégou B, Pinon-Lataillade ...
  • World Health Organization. 2010. Department of Reproductive Health and Research. ...
  • Zhang H, Wei K, Zhang M, Liu R, Chen Y. ...
  • نمایش کامل مراجع