Helicobacter pylori and Migraine: Is Eradication of Helicobacter pylori Effective in Relief of Migraine Headache
محل انتشار: علوم اعصاب کاسپین، دوره: 2، شماره: 4
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 330
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شناسه ملی سند علمی:
JR_CJNS-2-4_004
تاریخ نمایه سازی: 18 اسفند 1397
چکیده مقاله:
Background: Association between Helicobacter pylori (HP) infection and migraine and the effect of HP eradication on relief of migraine headache have been studied but the results are controversial. Objectives: To evaluate the effect of HP eradication in treatment of patients affected by migraine. Materials and Methods: Eighty consecutive HP infected patients affected by migraine without aura were enrolled in this clinical trial. They have referred to an endoscopy clinic for work-up of HP infection from October 2013 to November 2014. Patients were randomly assigned in 2 groups using 2 different regimens; Group A: migraine treatment and a 14-day triple therapy for HP infection and Group B: migraine treatment without HP eradication. The mean duration (hour), headache severity (MIDAS) and the frequency (per month) of clinical headache attacks were calculated upon enrollment in the study and at 6 months and 12 months after treatment. All data were analyzed using SPSS version 16. Comparison of categorical variables across the groups was performed using Chi-square test. Results: In group A, HP infection was eradicated in 34 of 40 patients (85%). After treatment in eradicated patients compared with the control group there was significant decrease in severity and frequency (but not in duration) of the migraine attacks at 6 months (p<0.001) and significant decrease in intensity, frequency and duration of the migraine attacks at 12 months (p<0.001). Conclusion: HP should be considered and examined in migranous patients and eradication treatment can be beneficial for relief of clinical attacks.
کلیدواژه ها:
نویسندگان
Mohammadreza Seyyedmajidi
MD, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Seyed-Amir Banikarim
MD, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Afsaneh Ardalan
MD, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran
Seyed Hossein Hozhabrossadati
MD, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Golestan University of Medical Sciences, Gorgan, Iran