Is Hemorrhagic Demyelinating Lesions of Central Nervous System a Spectrum

Small number of demyelinating diseases of the central nervous system (CNS) are associated with hemorrhage in the neural tissue, among which, the most well-recognizedis acute hemorrhagic leukoencephalitis (AHL). There have been reports of hemorrhage in other demyelinating diseases of the CNS. Investigating these cases can help us understand the less recognized symptoms of the demyelinating diseases of the CNS. hemorrhagic demyelinating lesions of CNS (HDLC) can be defined as per the following criteria: 1. Hemorrhage should be definitely revealed by imaging; 2. Hemorrhagic lesions must have a hemorrhagic mechanism due to CNS tissue demyelination; 3. Other possible differential diagnoses such as autoimmune encephalitis, vasculitis, and vasculopathy should be evaluated and ruled out.