Modulatory effect of aerobic training on some inflammatory profile indicators in obese females

Introduction: It is widely accepted that low grade systemic inflammation plays a keyrole in obesity and related diseases and metabolic syndrome. The objective of this workwas to evaluate the effect of aerobic training intervention on CRP and IL-10 in adult obesefemales.Methods: Thirty adult obese women (30≤BMI≤36) aged 30 to 40 years wererandomly assigned to exercise (3 months aerobic training, 3 time per week at 60-75% ofmaximum heart rate, n=15) and control (no training, n=15). At baseline and after 3months, anthropometrical indexes as well fasting serum IL-10 and CRP were assessed in2 groups. Inter and intra-group changes were analyzed by independent and paired sampleT test. P<0.05 was considered statistically signigcant.Results: After the 3 months of aerobic intervention, a significant decrease were observed inBMI, abdominal circumference, body weight, body fat (%) and visceral fat of exercisesubjects (P<0.05). No significant difference was found in all variables between 2 groups atbaseline (P> 0.05). Aerobic intervention resulted in significant increase in serum IL-10(from 14.79±3.04 to 17.79±3 pg/ml, P=0.001) and decrease in CRP (from 5670±1971 to3848±1092 ng/ml, P=0.002). All variables remained no change in control subjects(P> 0.05).Conclusion: With emphasis on IL-10 and CRP, long-term aerobic training can beconsidered as a anti-inflammatory treatment in sedentary obese females.

کلیدواژه ها:

Aerobic Exercise ، Adipose Tissue ، Inflammation ، Weight Loss