Antibiotic Resistance of Vibrio cholerae Isolates from Kashan, Iran
محل انتشار: نشریه بین المللی علوم بهداشت، دوره: 3، شماره: 2
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 300
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شناسه ملی سند علمی:
JR_IAHS-3-2_007
تاریخ نمایه سازی: 3 اسفند 1398
چکیده مقاله:
Aims Cholera is an acute diarrheal disease that can lead to severe dehydration and death.Antibiotic resistance is a big challenge in infective disease like Cholera. The present studyaimed to understand the characteristics and trends of antibiotic resistance of V. choleraeisolations in and around Kashan, Iran.Instrument & Methods In this descriptive cross-sectional study, samples were gatheredusing census method from 1998 to 2013 in Kashan, Iran. 1132 fecal samples of patientswith acute diarrhea and 237 samples of suspected water samples were taken. The serotypesand biotypes were determined by an enzymatic method. Antibiotic susceptibility test wasperformed by using Disk Diffusion Method. Data were analyzed using SPSS 23 software.Fisher-exact and Chi-square tests were used to compare the statistical parameters.Findings 96 fecal samples (8.5%) and 18 water samples (7.6%) were positive for Vibriocholerae. Non-agglutinating (Nag) isolates (75.4%) were more common than serotype Inaba(13.2%) and Ogawa (11.4%). Nag serotypes were mostly resistant to cefixime (44%) andampicillin (33%). In contaminated water samples also the most frequent cases were Nagserotype (50%). Nag serotype showed 22.2% of resistance to ampicillin and nitrofurantoin.Conclusion Vibrio cholerae isolates in Kashan, Iran, are highly resistant to antibiotics,especially Nag serotypes.
کلیدواژه ها:
نویسندگان
H Afzali
MD, Infectious Disease Department, Medicine Faculty, Kashan University of Medical Sciences, Kashan, Iran
M Momen-Heravi
MD, Social Determinants of Health (SDH) Research Center and Infectious Disease Department, Medicine Faculty , Kashan University of Medical Sciences, Kashan, Iran
R Razzaghi
MD, Infectious Disease Department, Medicine Faculty, Kashan University of Medical Sciences, Kashan, Iran