An experimental study of the systemic alteration of nitroimidazoles in the middle stage of embryonic development
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 628
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شناسه ملی سند علمی:
JR_IJABBR-2-5_016
تاریخ نمایه سازی: 26 اسفند 1394
چکیده مقاله:
Nitroimidazole compounds have been traditionally used in the veterinary and human medicine, but their uses are sometimes associated with some side effects. Toxicopathological effects of nitroimidazoles have always been a major concern. There is scant information available about thepathological alterations of nitroimidazole compounds in the embryo. The objective of this study was todetermine the macroscopic and microscopic lesions of metronidazole in the chicken embryo. Fertilebroiler eggs were divided into two equal treatment groups as follows: group 1: saline- injected group, the eggs were injected with sterile physiological saline solution into the chorioallantoic sac. Group 2, individuals were injected with metronidazole at a dosage of 25 mg/Kg egg-weight three times into the chorioallantoic sac. Macroscopically, the embryos were stunted. The feet and wings were small and thefeather formation was seriously affected. In this group, the embryos were affected by schistosomus reflexus. Microscopically, all organs were hyperemic. Based on macroscopic and microscopic findings, it is concluded that metronidazole at the above-mentioned concentration is toxic to thechicken embryo. The current study also advises caution in the extended use of nitroimidazole compounds.
کلیدواژه ها:
نویسندگان
Seyede Saeedeh Mosallanejad
Graduate student, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Hadi Tavakkoli
Department of Avian Medicine, School of Veterinary Medicine, Shahid Bahonar University of Kerman,Kerman, Iran
Amin Derakhshanfar
Center of comparative&experimental medicine, Basic sciences in infection diseases research center, School of medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Sajedeh Salandari
School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran