Bilateral primary breast lymphoma (PBL); case report

Extranodal lymphomas account for 10– 40% of all malignant Lymphomas [1].The most common anatomic site of a primary extranodal lymphoma is the gastrointestinal tract (stomach and ileocoecal region), but virtually any extranodal location may be a primary site including the skin, CVS, bone, testis, soft tissue, thyroid, etc.Primary breast Lymphomas (PBL) account for 1.7% to 2.2% of extranodal Lymphomas, 0.04% to 1.1% of breast neoplasms, and 0.38% to 0.7% of non-Hodgkin s Lymphomas [2, 3, 4].The predominant pathologic type of PBL is diffuse large B-cell Lymphomas, but other types can be found [3, 5, 6].The median age of patients diagnosed with PNHLB is between 40 and 67 yr, but the range is broad; thus, these tumors can appear in teenagers or patients in their 90’s, the peak age incidence usually is during the sixth decade [7, 15].All published series reported an overwhelming female predominance [7- 9]. The clinical presentation of lymphoma in the breast is similar to other breast malignancy, with a single or multiple painless masses in breast parenchyma. About 13% of patients have bilateral breast involvement. Axillary nodes are involved in 30-40% of cases.Radiographic imaging features of PBL are nonspecific, with the exception that calcifications are rare [10, 11].