Applying the Taguchi Method for Optimized Fabrication of Lactalbumin Nanoparticles as Carrier in Drug Delivery and Food Science

سال انتشار: 1389
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 1,069

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شناسه ملی سند علمی:

JR_IJEE-2-1_012

تاریخ نمایه سازی: 1 اردیبهشت 1393

چکیده مقاله:

Protein nannoparticles fabrication as well as characterization have been extensively studied in our previous works as suitable carrier for drug delivery and food science, since they are biodegradable, non-toxicand non antigenic. The objective of the present study was to optimize the fabrication of -lactalbuminnanoparticle by applying the Taguchi robust method which is a statistical approach to overcome the limitation of the factorial and fractional factorial experiments. The process variables were pH, temprature and agitation speed. The optimal levels of the different factors for the nanoparticle production based on coacervation methodwere pH 2.5, temperature 50°C and 750 rpm for agitation speed. The nanoparticle size at the determinedcondition was less than 220 nm. The mechanistic of the optimum conditions for preparing -lactalbumin nanoparticles and their characterization as a drug delivery vehicles are strongly discussed

کلیدواژه ها:

-lactalbumin % Nanoparticles % Drug carrier % Optimization % Taguchi method

نویسندگان

Rabeah Mehravar

Faculty of Chemical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran

Mohsen Jahanshahi

Faculty of Chemical Engineering, Nanotechnology Research Institude,Babol University of Technology, Babol, Iran

Ghasem D. Najafpour

Faculty of Chemical Engineering, Nanotechnology Research Institude,Babol University of Technology, Babol, Iran

Naser Saghatoleslami

Faculty of Chemical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran