Pharmacotherapy to Improve the Acquired Aphasia following Brain Damages: A Review Study
محل انتشار: مجله جراحی مغز و اعصاب ایران، دوره: 1، شماره: 2
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 599
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شناسه ملی سند علمی:
JR_IJN-1-2_001
تاریخ نمایه سازی: 15 شهریور 1395
چکیده مقاله:
Background & Aim: Using pharmaceutical agents in treatment of aphasia has caught the attention of many neurologistsand neuroscientists. This short review study has sought the role of pharmacotherapy in treatment of aphasia, a linguisticimpairment after acquired brain lesions. The pharmacological principles and mechanisms related to the effects of drugsused in aphasia rehabilitation are pointed. Then, some evidence of clinical trials on different drugs in this field ispresented.Methods & Materials/Patients: A comprehensive search in databases including MEDLINE, Cochrane, PubMed,Scopus, EMBASE, Science Direct on experimental studies and clinical trials associated with pharmacotherapy ofaphasia after neurological damages was performed.Results: Pharmacological interventions through manipulating neurochemical levels in synapses, the pre- and postsynapticspaces and even inside neurons start to modulate the disturbed balance of neurotransmitters due to brainlesions. Pharmacotherapy is based on the principle that drugs via balancing the molecular signaling cascades triggereddue to neuronal damage can restore the function of neurons, facilitate the brain plasticity process and improve thelinguistic deficits in aphasic patients. Among the drugs that have been studied in treatment of aphasia, those acting oncentral cholinergic and glutamergic systems were more effective and led to better clinical outcomes.Conclusion: Although existing evidence has proved the pivotal role of pharmacotherapy in treatment of aphasia afteracquired brain lesions in adults, further research is required to assure the clinicians in using pharmacotherapy as astandard approach in treatment of aphasia.
کلیدواژه ها:
نویسندگان
Sara Ramezani
Ph.D Candidate, Neuroscience Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences,Tehran, Iran
Shahrokh Yousefzadeh-Chabaok
MD, Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan,Iran.
Mahdieh Sarraf-Razavi
Ph.D Candidate, Neuroscience Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences,Tehran, Iran