Comparison of Mast Cells Count in Odontogenic Cysts Using Histochemical Staining

سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 593

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شناسه ملی سند علمی:

JR_IJP-10-2_014

تاریخ نمایه سازی: 13 مرداد 1394

چکیده مقاله:

Background & Objectives: Odontogenic cysts are among the most frequent destructive lesions of jaws which their pathogenesis and growth mechanism are not cleared. With respect to different roles of mast cells, they may play a role in the pathogenesis and growth of odontogenic cysts. The aim of present study was to evaluate mast cells in the most common odontogenic cyst. Methods: Thirty paraffin-embedded tissue blocks including 10 radicular cysts, 10 dentigerous cysts and 10 odontogenic keratocysts were used and 5 micron sections stained with toluidine blueand observed by light microscope under ×400 magnification to evaluate mast cells within these cysts. For each case, 5 high-power field areas, selected from hot-spot areas, were considered and each area divided into 3 zones: intra-epithelial zone, sub-epithelial zone and deep zone.Results: Most of the studied cyst showed presence of mast cells. There was not any significantdifference in mast cell count between studied cysts (P-values > 0.05).With respect to intra-epithelial, sub-epithelial and deep zones, there was not any significant difference between three studied cysts. There was not any significant difference between sub-epithelial zone and deep zone within each of these cysts. There was only significant difference between intra-epithelial zone and sub-epithelial zone within dentigerous cysts and odontogenic keratocysts (P-value < 0.05). Conclusion: Prevalence of mast cells in fibrous wall of odontogenic cysts suggests their activity in these cysts. Mast cells may not be directly involved in the pathogenesis of odontogenic keratocysts.

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نویسندگان

Mahdieh Rajabi-Moghaddam

Dept. of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Hamid Abbaszadeh-Bidokhty

Cellular and Molecular Biology Research Center, Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran

Ali Bijani

Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran