Serum Soluble Intercellular Adhesion Molecule-1 in Normal Pregnant Women and Those with Pre-eclampsia
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 2، شماره: 4
سال انتشار: 1386
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 561
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شناسه ملی سند علمی:
JR_IJP-2-4_006
تاریخ نمایه سازی: 5 آبان 1393
چکیده مقاله:
Background and Objective: Pre-eclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal riskof cardiovascular disease later in life. Endothelial dysfunction is thought to be a central pathogenicfeature in pre-eclampsia on the basis of elevated adhesion molecules. The aim of the present study was to compare the level of soluble intercellular adhesion molecule-1 (sICAM-1) in sera of normal and pre-eclamptic pregnancies. Materials and Methods: In this cross-sectional study, we studied the serum level of sICAM-1in peripheral blood obtained from normal pregnant women (n = 40), mild pre-eclampsia (n = 37) andsevere pre-eclampsia (n = 38). Concentration of soluble adhesion molecule was determined usingenzyme-linked immunosorbant assay (ELISA).Results: There was no difference in the mean plasma sICAM-1 between normal pregnant womenand mild pre-eclamptic women. Serum concentration of sICAM-1 was significantly higher in severe pre-eclampsia (p<0.05) than normal pregnancy. There was also significant differences in s ICAM- 1 levels between mild and severe pre-eclampsia (p<0.05). Conclusion: These results suggest that soluble intercellular adhesion molecule-1 is increased in severe pre-eclampsia, and sICAM-1 may be useful in predicting the severity of pre-eclampsia.
کلیدواژه ها:
نویسندگان
Mehdi Farzadnia
Dept. of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
Hossein Ayatollahi
Dept. of Biochemistry and Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Malihe Hasan-zade
Dept. of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran
Sakine Amooeian
Dept. of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran