Seroprevalence of IgG Antibodies against Bordetella pertussis in Different Age Groups in Tehran, Iran

سال انتشار: 1391
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 650

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_IJP-7-3_006

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Background and Aims: Pertussis is a highly contagious, vaccine-preventable disease. Determination of the seroepidemiology of pertussis makes possible the evaluation of pertussis immunity in a population. In this study, we determined the seroprevalence of Bordetella pertussis IgG antibodies in different age groups in Tehran, Iran.Materials and Methods: Overall, 1101 subjects between ages of 8 months and 20 years were tested for the presence of pertussis toxin (PT), filamentous hemagglutinin (FHA) and different lipopolysaccharides (LPS) antibodies by ELISA.Results: The overall prevalence of pertussis antibodies was 48% and the mean antibody level was 44± 47.7 U/ml. Over half (53.1%) of the children aged 8 months to 6 years were negative for pertussis antibodies. Pertussis antibodies rates and levels were significantly different between age groups (P < 0.001) and their significant elevations were observed with increasing age.Conclusion: Up to half of the vaccinated children lacked an antibody response to vaccine, so using a more immunogenically effective vaccine to ensure sufficient immunity is essential. We showed that B. pertussis infection is on the rise in Iranian adolescents and young adults. Booster vaccination of this age group appears to be the most logical approach to disease prevention in adolescents and control the circulation of the organism.

کلیدواژه ها:

نویسندگان

Ali Eslamifar

Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran

Amitis Ramezani

Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran

Mohammad Banifazl

Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran

Akbar Khadem-Sadegh

Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran