Histological changes in testes of rats treated with testosterone, nandrolone, and stanozolol

Background: Anabolic androgenic steroids (AAS) is being used in medical treatments, but AAS also was identified to have the risks of adverse effects towardspatients and consumers health. Objective: Present study was conducted to observe the effects of testosterone, nandrolone, and stanozolol (forms of AAS) intake during onset of puberty on the rattesticular histology. Materials and Methods: Juvenile male Sprague-Dawley (SD) rats (n=42) weredivided into seven groups and were injected subcutaneously with medium dose of polyethylene glycol-200 (PEG-200) (control), testosterone, nandrolone, andstanozolol for six weeks (PND 41-87). The animals were weighed daily and sacrificed on PND 88. Testes were removed, weighed, and prepared for histologicalassessment and finally specimens were observed under microscope. Results: The results showed an insignificant increase in mean daily body weightwith highest and lowest body weight gained was of 177.6±1.69 gr and 140.0±12.26 gr respectively. There was significant decrease in the testes absolute weight (p≤0.01) in all experimental groups except in the nandrolone 2.5 mg/kg/week treated group.Testicular histology of rats treated with AAS also showed slight changes in the uniformity of arrangements of seminiferous tubules.Conclusion: Data from present study suggests that AAS have been initiating the adverse effects on testicular normal functions in rats during onset of puberty

کلیدواژه ها:

Testosterone ، Nandrolone ، Stanozolol ، Testes ، Substance abuse