Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family

سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 434

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شناسه ملی سند علمی:

JR_IJRM-11-8_009

تاریخ نمایه سازی: 16 شهریور 1395

چکیده مقاله:

Background: Recurrent spontaneous abortion (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified. Objective: In this study we performed linkage analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA. Materials and Methods: A linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-linked RSA. Two point parametric Linkage was performed using Superlink v 1.6 program. Results: Evidence of linkage was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively. Conclusion: Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this gene

نویسندگان

Sahar Shekouhi

Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Baghbani

Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Hasanzadeh Nazar-Abadi

Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Tayebeh Hamzehloie

Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran