Effects of glycowithanolides on lipid peroxidation and lipofuscinogenesis in male reproductive organs of mice
محل انتشار: مجله طب تولید مثل ایران، دوره: 11، شماره: 9
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 324
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شناسه ملی سند علمی:
JR_IJRM-11-9_003
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: Glycowithanolides (Withaferin A), is one of the main withanolides active principle isolated from plant Withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties.Objective: In the present investigation, antioxidant activity of active principles of Withania somnifera was tested against D-galactose induced oxidative stress in mouse testes, epididymis and seminal vesicle.Materials and Methods: For the present investigation Swiss male albino mice Mus musculus (Linn) were used. They were grouped in to control (I), D-galactose treated (II), protective (III) and curative groups (IV). Oxidative stress was induced in six month old mice by injecting a low dose of D-galactose. Antioxidant effect of plant extract was studied in testes, epididymis, and seminal vesicle of oxidative stressed mice on Lipid peroxidation (LPO) and fluorescence product.Results: In the present study, both total as well as mitochondrial lipid peroxidation and fluorescence product in testes, epididymis and seminal vesicle were increased in D-galactose induced mice. After the treatment of glycowithanolides there was significantly decrease in total as well as mitochondrial lipid peroxidation and fluorescence product in protective and curative groups.Conclusion: Our results indicate that Withania somnifera has a capability of preventing oxidative stress and also combating stress induced infertility
کلیدواژه ها:
نویسندگان
Madhuri Walvekar
Department of Zoology, Shivaji University, Kolhapur, India.
Nilofar Shaikh
Department of Zoology, Shivaji University, Kolhapur, India.
Priti Sarvalkar
Department of Zoology, Shivaji University, Kolhapur, India.