The differential expression of microRNA-143,145 in endometriosis
محل انتشار: مجله طب تولید مثل ایران، دوره: 12، شماره: 8
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 328
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شناسه ملی سند علمی:
JR_IJRM-12-8_004
تاریخ نمایه سازی: 16 شهریور 1395
چکیده مقاله:
Background: Recent studies showed that inappropriate expression of microRNAs (miRNAs) is strongly associated with tumor-related processes in humans (2-9,11-17). Objective: To understand the changes of miRNAs in endometriosis. Materials and Methods: With real-time RT-PCR, we investigated the miR-143 and miR-145 expression in eutopic (EU, n=2) and ectopic endometrium (EC, n=11) (from women with endometriosis) (as well as EU+EC, n=11), along with the normal endometrium (EN, n=22) (from women without endometriosis, but with leiomyoma). Results: We did not find that the expression of miR-143 and/or miR-145 in EN or EC changed with menstrual cycle. But our results showed the miR-143 was up-regulated in EC (p=0.000) compared to EN. The miR-143 was also up-regulated in EU, but the difference did not reach statistically significance (p=0.053). Compared to EU, the expression of miR-143 in EC was up-regulated (p=0.016). MiR-145 had the similar characteristic to miR-143. The miR-145 was up-regulated in both EU (p=0.004) and EC (p=0.000) in compared to EN group. When compared with EU, the miR-145 in EC was up-regulated (p=0.008). Conclusion: In conclusion, the miR-143 and miR-145 may play a certain role in the development and progression of endometriosis.
کلیدواژه ها:
نویسندگان
Bingbing Zheng
Department of Obstetrics, First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China
Xiangyang xue
Department of Microbiology, Wenzhou Medical University, Zhejiang, China
yiping zhao
Department of Gynecology, Zhuji People's Hospital, Zhejiang, China
jing chen
Department of Reproductive Medicine, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, China