N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 337

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شناسه ملی سند علمی:

JR_IJRM-15-4_003

تاریخ نمایه سازی: 2 آبان 1396

چکیده مقاله:

Background: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citratefor ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance.Objective: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination.Materials and Methods: In this randomized clinical trial 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1.2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed Daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, GONALF was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, HCG (10000 IU) was injected intramuscular and the intrauterine insemination was performed after 34-36 hr.Results: There were not significant differences between study groups regarding mean endometrial thickness (p=0.14), mean number of mature follicles (p=0.20) and the pregnancy rate (p=0.09).Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients.

نویسندگان

Tahereh Behrouzi Lak

Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran.

Masoomeh Hajshafiha

Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran.

Fariba Nanbakhsh

Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran.

Sima Oshnouei

Department of Obstetrics and Gynecology, Urmia Reproductive Health Research Center, Urmia, Iran.