Subchronic effects of different doses of Zinc oxide nanoparticle on reproductive organs of female rats: An experimental study

سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 506

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

این مقاله در بخشهای موضوعی زیر دسته بندی شده است:

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_IJRM-17-2_004

تاریخ نمایه سازی: 28 مهر 1398

چکیده مقاله:

Background: Zinc performs many biochemical and physiological functions; however,toxicological studies demonstrate that Nano-zinc oxide has harmful effects on humanhealth and environmental species in high concentrations.Objective: The aim of this study was to investigate the toxicity of zinc oxidenanoparticles on reproductive tissues of female rat.Materials and Methods: Eighty female Wistar adult rats weighing 180–200 gr, dividedinto eight groups (n= 10 in each group) including control, sham (treated with saline),and six groups injected with different doses of zinc oxide nanoparticle with 10–30nanometer size (4, 8, 25, 50, 100, and 200 mg/kg) twice a week for four weeks. Atthe end of the study, the rats were bled and slaughtered; the Ovary and Uterus weretaken for histopathology studies and blood samples were transferred to the laboratoryfor biochemical analysis.Results: Microscopic diagnoses in ovary tissue were included; increase in the corpusluteum, follicular cysts, inflammatory cells infiltration and fibrosis. Histopathologicalchanges in ovary in a dose-dependent manner. In uterus tissue the lesions consisted;epithelial destruction, hyperplasia of endometrial glands. The Estrogen and Progesteronelevel in the serum of rats increased in low doses and reduced in a dosedependentmanner at high doses.Conclusion: The results of the current study proved the toxicity of zinc oxidenanoparticles on the ovary and uterus organs at high concentrations, so furtherinvestigation is needed to reduce these effects.

کلیدواژه ها:

نویسندگان

Seyed Mohammad Hosseini

Ph.D., Department of Pathology, Babol Branch, Islamic Azad University, Babol, Iran

Amir Hossein Moshrefi

DVM, Young Researchers and Elite Club, Babol Branch, Islamic Azad University, Babol, Iran

Reza Amani

DVM, Young Researchers and Elite Club, Babol Branch, Islamic Azad University, Babol, Iran

Seyed Vahid Razavimehr

DVM, Young Researchers and Elite Club, Babol Branch, Islamic Azad University, Babol, Iran