Comparing endometrial hysteroscopic and histological findings of infertile women with polycystic ovary syndrome and unexplained infertility: A cross-sectional study

Background: Infertility is a critical condition in women with polycystic ovary syndrome(PCOS), caused not only by anovulation but also by endometrial abnormality.Objective: This study aimed to evaluate and compare the hysteroscopic andhistological findings of endometrial biopsies in infertile women with PCOS and normalendometrial thickness and women with unexplained infertility (UI).Materials and Methods: This cross-sectional study compared the initial hysteroscopyand endometrial histological findings of 70 infertile women with PCOS and normalendometrial thickness with those of 35 women with UI. The relationship betweenendometrial histology and clinical parameters such as including luteinizing hormone,follicle-stimulating hormone, thyroid-stimulating hormone, testosterone, prolactin,fasting blood sugar, body mass index (BMI), and infertility duration was analyzed.Results: The mean age of women with PCOS was significantly lower than that ofwomen with UI (27.5 ± 4.1 vs. 30 ± 4.5 years, respectively) (p < 0.001). The meanBMI was higher in women with PCOS than in women with UI (28.7 ± 4.4 vs. 25.1 ±3 kg/m2) (p < 0.001). The hysteroscopic findings of all women with PCOS were normal,whereas 91.4% of women with UI had normal hysteroscopic findings, 2.9% had a polyp,and 5.7% had endometrial thickening. The histological findings of women with PCOSrevealed proliferative endometrium in 54.3%, disordered proliferative endometrium in17.1%, secretory endometrium in 8.6%, and endometrial polyp in 17.1%, whereas thesepercentages in women with UI were 28.6%, 0%, 54.3%, and 20%, respectively.Conclusion: The hysteroscopic evaluation alone of infertile women might not detect allprobable endometrial pathologies in women with PCOS.

کلیدواژه ها:

Polycystic ovary ، Hysteroscopy ، Histology ، Endometrium ، Infertility