Synovial fluid inflammatory cytokines and proteins in clinicallyhealthy and arthritic joint of dromedary camels (Camelusdromedarius)
محل انتشار: فصلنامه طب دامی ایران، دوره: 8، شماره: 1
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 431
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شناسه ملی سند علمی:
JR_IJVM-8-1_009
تاریخ نمایه سازی: 26 اردیبهشت 1394
چکیده مقاله:
BACKGROUND:Background: Analyzing the synovial fluid is one of the common methods to diagnose the articular problems to detect the stage and express the prognosis. Such gross, cytological, and biochemical analysis of synovial fluids can aid in the diagnosis of various joint diseases. OBJECTIVES: Normal values for synovial fluid in the camels have been described previously; however, there are no reports regarding concentration of acute phase proteins and inflammatory cytokines incamelids synovial fluid. Hence, the present study tried to compare the synovial fluid inflammatory cytokines and acute phase proteins in clinically healthy and arthritic tarsal joints of dromedary camels. METHODS: 46 male dromedary camels, 5 to 10 years old, were used in this study. 33 camels did not have any clinical articular abnormalities while 13 camels had gross articular problems such as lameness and swollen tarsal joints. Collecting the synovial fluids was extracted from the healthy andarthritic tarsal joints immediately after slaughter. Then, the concentration of haptoglobin, serum amyloid A, tumor necrosis factor-alpha, and interferon-gamma were measured in samples. RESULTS: Concentration of all measured parameters in arthritic joints were significantly higher than clinically healthy joints (p<0.05). The synovial fluid concentration of serum amyloid A, haptoglobin, tumor necrosis factor-alpha, and interferongamma were 5.379, 4.285, 25.503, and 1.904 times higher inarthritic joints than normal joints, respectively. CONCLUSIONS: The articular inflammatory processes can increase the synovial fluid concentration of acute phase proteins and inflammatory cytokines. Information about the normal values of these parameters and their changing patterns may help camel rearing systems during arthrititis by assessing the health status of joints in the camels; in addition, the information about normal values can be diagnostically valuable when considering diseasedanimals.
کلیدواژه ها:
نویسندگان
M.H Najizadeh
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
M Pourjafar
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
A. Chalmeh
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Kh Badiei
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran