Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 445
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شناسه ملی سند علمی:
JR_IJVST-5-2_005
تاریخ نمایه سازی: 13 تیر 1396
چکیده مقاله:
Platelets are a natural source of growth factors and cytokines that promote wound healing, and platelet-rich fibrin contains concentrated growth factors. Growth factors in platelet-rich fibrin may promote wound repair. In this study the effect of platelet-rich fibrin was evaluated in a dog model of cutaneous incisional wounds using histology and semi-quantitative evaluation. One pair of ten-centimeter full-thickness parallel linear cutaneous wounds were created on the backs of 15 dogs on the both sides of vertebral column. On the left side the platelet-rich fibrin clot was applied to the edges of the wound (Treatment group) and the right side received nothing (Control group). All wounds were then closed with 3-0 non-absorbable Nylon suture. The dogs were divided into three groups of five dogs. The wound tissues were sampled by electrosurgery in group one after 3 days, group two after 7 days and group three after 14 days post surgery. For each specimen, histopathological examination and semi-quantitative evaluation was performed by light microscopy using Hematoxylin & Eosin and Masson’s trichrome staining. The results demonstrated that platelet-rich fibrin improved and accelerated cutaneous incisional wound healing
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نویسندگان
Majid Khanzadeh AlishahiP
PResearch Institute of Animal Breeding and Genetics, Abbas Abad, Mashhad, Iran
Davoud KazemiP
PDepartment of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Darioush MohajeriP
PDepartment of Pathobiology, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Hasan MofidpoorP
PDepartment of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran