Prevalence of Helicobacter Pylori in symptomatic patients post triple therapy eradication in Jordan

Background and Objective: Despite the use of triple therapy for H.pylori eradication, significant number of the patients still has same complaint. In view of their complaint and increase number of the studies showed decrease in the cure rate of triple therapy, we look at the prevalence of Helicobacter Pylori (HP) in symptomatic patients post a fourteen days’ course of triple therapy in documented HP gastritis by histopathology.Method and Materials: A retrospective study, which includes one hundred and five patients, whom underwent endoscopies for epigastric pain, from May2014 till February 2015,and have had gastric biopsies that showed chronic active gastritis with presence of HP. Triple eradication therapy in the form of omperazole 20mg BID, amoxicillin 1g BID and clarithromycin 500mg BID was given for 14 days. These patients were selected as they remain symptomatic post eradication therapy. The presence of HP after eradication was confirmed by stool antigen test six weeks after the end of treatment with complete avoidance of antibiotics, proton pump inhibitors and histamine 2 receptor antagonists during this period.Result: The rate of eradication in these symptomatic patients was 61.9%. Failure of eradication was seen in 33.3% of the male group (10 patients) and 40% of the female group (30 patients).Conclusion: Our study showed that triple therapy eradication rate was 61.9%, which is lower than international findings; this may be explained by fact that we only screened the symptomatic patient post eradication therapy and not all patients who received the course. Studies on HP sensitivity for antibiotic should be done to guide eradication regimens to reach acceptable eradication rates.

کلیدواژه ها:

Helicobacter Pylori ، Triple therapy ، Gastritis ، Stool Antigen test