Biological features of breast carcinoma in postmenopausal women

Background: Breast carcinoma is the most common cancer in females , its incidence increase with age . Theaim of this study is to analyses the biological features of breast carcinoma in postmenopausal women .Methods: Our study included 68 postmenopausal patients who underwent modified radical mastectomy in KingHussein Medical Center during the period between January 2012 and December 2014.We divided our patients into two groups : the first group was 46 Young postmenopausal patients ( YPM ) theirages from 50 to 64 years. The second group consisted of 22 elderly postmenopausal patients ( EPM ) who were65 years of age and above .Results: Both age groups ( YPM and EPM ) had the same range of tumor size which is 2 cm and above.Tumorsize was found in 80 % and 81 % respectively .YPM patients were found to have greater lymph node involvement 76 % in comparison to EPM which was 63% . They also showed that the incidence of peritumor vascular invasion in YPM is 60 % while in the EPMpatients is 50 %.Both age groups showed similar Estrogen and Progesterone receptor expression 80 % and 77 %respectively .Conclusion: Although both groups showed almost the same range of tumor size , older patients were found tohave tumors with more favorable biologic characteristics in comparison to younger age group in regard tolymph node involvement and peritumor vascular invasion . Tumor responsiveness to hormonal therapy wassimilar in both groups .

کلیدواژه ها:

Breast cancer ، Biologic features ، Postmenopausal women