Fecal Calprotectin: A Screening Marker for the Early Detection of Necrotizing Enterocolitis among Children in Egypt
محل انتشار: مجله علمی ناباروری ایران، دوره: 11، شماره: 2
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 217
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شناسه ملی سند علمی:
JR_IRJN-11-2_001
تاریخ نمایه سازی: 24 تیر 1399
چکیده مقاله:
Background: Necrotizing enterocolitis (NEC) is a lethal disease affecting newborns with significant morbidity and mortality rates. Moreover, it is the most eminent gastrointestinal threat affecting premature newborns. Unfortunately, early symptoms and signs are usually vague; therefore, there is a special demand for sensitive biomarkers in this regard. This study aimed to investigate the role of fecal calprotectin in stage I NEC and identify specific cut off value at this stage to differentiate stage I NEC from other gastrointestinal disorders.Methods: This cross-sectional study was conducted at New Children Hospital, Cairo University, Egypt. In total, 100 newborns were included in this study who were assigned to the patient group with stage I NEC (n=60) and control group (n=40)with age and gender-matched newborns.Fecal calprotectin level was assessed using an enzyme-linked immunosorbent assay in both groups. Follow up of the patient group was performed for the development of stage II or III NEC.Results: The patient group obtained significantly elevated levels of fecal calprotectin, compared to the control group (P=0.000). Within the patient group, 43 (71.66%) newborns developed stage II or III NEC, whereas 17 (28.33%) cases developed no NEC. In addition, the level of fecal calprotectin was significantly higher in the group who developed stage II or III NEC (P=0.001). According to the receiver operating characteristic (ROC) curve, the cutoff value of 109.5 μg/g feces showed 100% sensitivity and specificity, and the area under the ROC curvewas equal to 1 in differentiating NEC from other conditions.Conclusion: The study showed that fecal calprotectin can be used as a sensitive and specific marker for the early detection of necrotizing enterocolitis.
کلیدواژه ها:
نویسندگان
Ayman Emil Eskander
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Rania Hosni Tomerak
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mona Safwat
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Carolyne Ghobrial
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
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