Neuroprotective Effect of Coenzyme Q10 in Hippocampal Injury in Balb/c Mouse

سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 436

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شناسه ملی سند علمی:

JR_JABR-1-2_002

تاریخ نمایه سازی: 29 آذر 1395

چکیده مقاله:

Coenzyme Q10 is a promising agent for neuroprotection in neurodegenerative diseases. Neuroprotective effects of Coenzyme Q10 demonstrated in some neurodegenerativediseases such as Parkinson, Alzheimer and etc. Hippocampus is home of these diseases. We assayed Coenzyme Q10 effects on Hippocampal injury modeland our hypothesis is that Coenzyme Q10 has Neuroprotective effects in some neurodegenerative diseases via hippocampus. For this purpose 24 Balb/c mouse tookin 4 groups: Control (Without any treatment), Vehicle (Treated with sesame oil asCoenzyme Q10 vehicle), Hyppocampal injury model (Treated with Trimethyltin chlorideneurotoxin, 2.5 mg per kg IP), and test (Treated with Coenzyme Q10 afterTrimethyltin chloride injection, 10 mg per kg IP for 2 weeks). After two weeks brain harvested and hippocampus tissue assayed by Nissl and Tunnel staining. Hystologicalstudy showed significantly increase of normal cells and decrease of apoptotic cells in test group after Coenzyme Q10 treatment in hippocampus. This studyshowed Coenzyme Q10 has protective effects in hippocampus after injury and itseems that Neuroprotective effects of Coenzyme Q10 in some neurodegenerative diseases com from that

نویسندگان

Sara Rigi

Department of Anatomy, School of Medicine, Iran University of Medical Science, Tehran, Iran

Abolhassan Sakhaei

Department of Anatomy, School of Medicine, Iran University of Medical Science, Tehran, Iran

Azadeh Niknam Asl

Department of Tissue Engineering, Tehran University of Medical Science, Tehran, Iran

Akram Alizadeh

Department of Tissue Engineering, Tehran University of Medical Science, Tehran, Iran