Chemical Preparation of Beta Calcium Sulfate Hemihydrate Granules with a Special Particle Size as Bone Graft Material

سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 275

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شناسه ملی سند علمی:

JR_JDMT-3-4_005

تاریخ نمایه سازی: 20 مهر 1398

چکیده مقاله:

Introduction: Beta calcium sulfate hemihydrate (BCSH), which is commonly known as Gypsum plaster has long been used as bone graft material because of its excellent biocompatibility and the ability for bone regeneration. Several methods have been used for the preparation of BCSH, including heat treatment of calcium sulfate dihydrate with water, application of inorganic acids or condensed inorganic salt solutions under high or atmospheric pressure. As a bone graft, it is preferred that the BCSH powder has a granular form for the purpose of manipulation, bio-mechanical properties and ease of injection. Methods: For this study granules of BCSH in the size of 500 to 700 micrometers were manufactured and sterilized using gamma ray. For assessing the regeneration of thismaterial, six rabbits were selected and granules were injected in the bone defects that were made using diamond bur in their skull under general anesthesia. Biopsies for histological evaluations were done 3, 6, 9, 12, 14 and 16 months following surgery. Results: At the third month time-point, remodeling of the BCSH was evident, and complete newly formed bone was seen in the region of the defect. Conclusion: The results of this study demonstrated that BCSH had a good biocompatibility without inducing an inflammatory response and promoted bone healing.

کلیدواژه ها:

Beta calcium sulfate hemihydrate ، Bone graft ، granule

نویسندگان

Naser Sargolzaie

Department of Periodontics, Dental Material Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

Javad Sargolzaie

Department of chemical engineer, Ferdowsi University of Mashhad, Iran

Nasrollah Saghravanian

Oral and Maxillofacial Disease Research Center, Department of Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

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