The Effect of Ginger on Blood Lipid and Lipoproteins in Patients with Type 2 Diabetes: A Double-Blind Randomized Clinical Controlled Trial

Background: Preliminary clinical trials showed that ginger improved lipidprofile in type 2 diabetes patients (T2D). This trial was carried out to determinethe effect of ginger on blood lipid and lipoproteins in T2D. Methods: this is arandomized, double-blind, placebo-controlled trial on 88 T2D conducted in. Thepatients were randomly divided into two groups of ginger (GG) and placebo(PG), the GG consumed daily 3 one-gram capsules containing ginger powderwhereas the other group received capsules of the same color and number as GGbut containing cellulose microcrystalline, both after taking meals and for eightweeks. Serum total cholesterol (TC), triglycerides (TG), HDL-c, LDL-c, ApoB100 and Apo A1 were measured at the baseline and the end of trial. Results: Outof 88 patients who participated in the trial, 81 of them accomplished it. Nosignificant changes were observed in mean of TC, TG, HDL-c, and Apo B100within and between the groups. Serum LDL-c and LDL-c/HDL-c ratio weredecreased significantly in the GG (P = 0.03, P = 0.028) at the end of trail butthey were not significantly different between the two groups. Serum Apo A1 wasincreased significantly in the GG (P < 0.05) and PG (P < 0.05) at the end of trialbut it was not significantly different between the two groups. Conclusions: Thisstudy indicated that daily consumption of 3 g of ginger powder in capsules for 8weeks by T2D leads to lowering of LDL-c, LDL-c/HDL-c ratio, and Apo A1.Therefore, consumption of this supplementation is appropriate for this patients.

کلیدواژه ها:

Ginger ، Diabetes Mellitus ، Blood Lipids ، Lipoproteins