Does Omega-3 Fatty Acid Supplementation Have Beneficial Effects on Plasma Homocysteine, Insulin Resistance and Lipid Profile of Type 2Diabetic Patients A Randomized Clinical Trial
محل انتشار: فصلنامه تغذیه و امنیت غذایی، دوره: 3، شماره: 1
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 428
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شناسه ملی سند علمی:
JR_JNFS-3-1_007
تاریخ نمایه سازی: 27 مرداد 1397
چکیده مقاله:
Background: This study was conducted to determine the effects of n-3 PUFAssupplementation on plasma homocysteine (Hcy) level, lipid profile and insulinresistance in patients with type 2 diabetes (T2D). Methods: This study is adouble-blind controlled trial involving 70 patients with T2D selected from YazdDiabetes Research Center in 2013. Patients were randomly assigned to receiveeither 2 g/day omega-3 soft gels (OG) or 2 g/day placebo (PG) for 6 weeks. Atthe beginning and end of the study, Hcy concentration, fasting plasma glucose(FBG), fasting plasma insulin, total cholesterol (TC), triglycerides (TG), lowdensity lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol(HDL-c), HDL-c/LDL-c ratio, insulin resistance (HOMA-IR), insulin sensitivity(IS) and beta-cell function were measured and compared. Results: Sixty fiveparticipants completed the study. The results of this study showed thatomega-3 fatty acid supplementation caused significant increase in Hcy(P = 0.007) and LDLc (P = 0.02), while HDLc and HDLc/LDLc ratio weresignificantly decreased (P = 0.001 and 0.006, respectively). In both groups,insulin and HOMA-IR were increased, while IS decreased significantly. Βetacellfunction was increased only in OG (P = 0.005). There was no significantdifference in mean change of any factors. Conclusion: The present study foundno beneficial effects of 2 g/day omega-3 supplement for 6 weeks on biomarkersof Hcy, FBG, insulin and lipid profile in th T2D patients.
کلیدواژه ها:
نویسندگان
Faezeh Poursoleiman
MSc, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hassan Mozaffari-Khosravi
PhD, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran- Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Akram Naghidipour Biregani
MSc, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran