Synthesis and structural properties of polyvinylpyrrolidone based nanocomposite hydrogels for isoniazid drug delivery
محل انتشار: فصلنامه علوم و فناوری ذرات، دوره: 1، شماره: 3
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 403
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شناسه ملی سند علمی:
JR_JPST-1-3_006
تاریخ نمایه سازی: 26 فروردین 1397
چکیده مقاله:
In this study, several examples of hydrogels and nanocomposite hydrogels based on PVP with different content of montmorillonite nanoclay were prepared. Then, the swelling of hydrogels and kinetics of drug delivery of hydrogel in an environment similar to the body (pH 7.4) were examined. The effect of nanoparticle different percentages on the hydrogel was clearly observed. Then, kinetics of drug (Isoniazid) delivery for various samples of hydrogel with nanoparticles and without nanoparticles were obtained via Peppas and Higuchi models. The comparison of Peppas model results with experimental data showed that nanocomposite with 4 wt.% nanoclay exhibited better compliance. The morphology and microstructure of the prepared nanocomposites were studied by FT-IR, XRD and SEM
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نویسندگان
Hassan Fathinejadjirandehi
Young Researchers and Elite Club, Farahan Branch, Islamic Azad University, Farahan, Iran
Maryam ADIMI
Young Researchers and Elite Club, Farahan Branch, Islamic Azad University, Farahan, Iran
Mokhtar Heydari Naqdali
Department of Chemical Engineering, Farahan Branch, Islamic Azad University, Farahan , Iran