A Validated and Rapid HPLC Method for Quantification of Human Serum Albumin in Interferon beta-1a Biopharmaceutical Formulation
محل انتشار: مجله Medbiotech، دوره: 1، شماره: 1
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 401
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شناسه ملی سند علمی:
JR_MBT-1-1_004
تاریخ نمایه سازی: 10 خرداد 1399
چکیده مقاله:
Multiple sclerosis, or MS, is a long-lasting disease that can affect your brain, spinal cord, and the optic nerves in your eyes. It can cause problems with vision, balance, muscle control, and other basic body functions. IFN-beta treatment reduces the relapse rate in multiple sclerosis (MS), but the exact mechanism of action of the drug has remained elusive. CD73 (ecto-5 -nucleotidase) is an ectoenzyme, which produces adenosine from adenosine monophosphate (AMP) precursor by enzymatic dephosphorylation. In this study, a validated and rapid HPLC method for quantification of human serum albumin in interferon beta-1a biopharmaceutical formulation was developed and linearity, robustness, specificity, accuracy and precision of samples were determined.
کلیدواژه ها:
نویسندگان
Somayyeh Heidary
Department of Cell and Molecular Biology, Universiti Putra Malaysia, Serdang, Malaysia
Mohsen Imani
Cinnagen Pharmaceutical Company, Karaj, Iran
Seyed Mojtaba Mostafavi
ACROSS Centre (Australian Centre for Research on Separation Science) University of Tasmania Hobart, Australia