Evaluation of loading efficiency of azelaic acid-chitosan particles using artificial neural networks

سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 361

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شناسه ملی سند علمی:

JR_NAMJ-3-3_004

تاریخ نمایه سازی: 18 تیر 1398

چکیده مقاله:

Objective(s): Chitosan, a biodegradable and cationic polysaccharide with increasing applications in biomedicine, possesses many advantages including mucoadhesivity, biocompatibility, and low-immunogenicity. The aim of this study, was investigating the influence of pH, ratio of azelaic acid/chitosan and molecular weight of chitosan on loading efficiency of azelaic acid in chitosan particles. Materials and Methods:  A model was generated using artificial neural networks (ANNs) to study interactions between the inputs and their effects on loading of azelaic acid. Results: From the details of the model, pH showed a reverse effect on the loading efficiency. Also, a certain ratio of drug/chitosan (~ 0.7) provided minimum loading efficiency, while molecular weight of chitosan showed no important effect on loading efficiency.Conclusion: In general, pH and drug/chitosan ratio indicated an effect on loading of the drug. pH was the major factor affecting in determining loading efficiency.

کلیدواژه ها:

Azelaic acid ، Artificial neural networks (ANNs) ، Chitosan ، Loading efficiency

نویسندگان

Ali Hanafi

Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Mehdi Kamali

Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Mohammad Hasan Darvishi

Nanobiotechology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Amir Amani

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran|Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran

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  • Mourya VK, Inamdar NN. Chitosan-modifications and applications: Opportunities galore. React ...
  • Jayakumar R, Prabaharan M, Reis RL, Mano JF. Graft copolymerized ...
  • Jayakumar R, Nwe N, Tokura S, Tamura H. Sulfated chitin ...
  • Jayakumar R, Prabaharan M, Nair SV, Tokura S, Tamura H, ...
  • Kumar MN, Muzzarelli RA, Muzzarelli C, Sashiwa H, Domb AJ. ...
  • Jayakumar R, Prabaharan M, Sudheesh Kumar PT, Nair SV, Tamura ...
  • Rinaudo M. Chitin and chitosan: Properties and applications. Prog Polym ...
  • Suh JK, Matthew HW. Application of chitosan-based polysaccharide biomaterials in ...
  • Fu H, Kobayashi T. Self-assembly functionalized membranes with chitosan microsphere/polyacrylic ...
  • Breathnach A, Levi-Montalcini R. The story of azelaic acid. A ...
  • Passi S, Picardo M, Nazzaro-Porro M, Breathnach A, Confaloni AM, ...
  • Nazzaro-Porro M, Passi S. Identification of tyrosinase inhibitors in cultures ...
  • 1978; 71(3): 205-208. ...
  • Schallreuter KU, Wood JM. Azelaic acid as a competitive inhibitor ...
  • Galhaup I. Azelaic acid: mode of action at cellular and ...
  • Passi S, Picardo M, De Luca C, Breathnach AS, Nazzaro-Porro ...
  • Passi S, Picardo M, Zompetta C, De Luca C, Breathnach ...
  • Fitton A, Goa KL. Azelaic acid. A review of its ...
  • Vyas SP, Gupta S. Optimizing efficacy of amphotericin B through ...
  • Meier W. Polymer nanocapsules. Chem Soc Rev. 2000;29(5):295-303. ...
  • Pathak Y, Thassu D. Drug Delivery Nanoparticles Formulation and Characterization: ...
  • Gad SC. Pharmaceutical Manufacturing Handbook: Production and Processes: Wiley; 2008. ...
  • Xu Y, Du Y. Effect of molecular structure of chitosan ...
  • Genta I, Perugini P, Pavanetto F. Different molecular weight chitosan ...
  • Wang SB, Chen AZ, Weng LJ, Chen MY, Xie XL. ...
  • Modaresi SMS, Faramarzi MA, Soltani A, Baharifar H, Amani A. ...
  • Alsarra IA, Betigeri SS, Zhang H, Evans BA, Neau SH. ...
  • Zhang H, Oh M, Allen C, Kumacheva E. Monodisperse Chitosan ...
  • Gan Q, Wang T. Chitosan nanoparticle as protein delivery carrier—Systematic ...
  • Patel JL, Goyal RK. Applications of artificial neural networks in ...
  • Behzadi SS, Prakasvudhisarn C, Klocker J, Wolschann P, Viernstein H. ...
  • Amani A, York P, Chrystyn H, Clark BJ. Factors affecting ...
  • Khayet M, Cojocaru C, Essalhi M. Artificial neural network modeling ...
  • Mansour AM, Ibrahiem MM. Simultaneous determination of azelaic and benzoic ...
  • Amani A, York P, Chrystyn H, Clark BJ, Do DQ. ...
  • Aghajani M, Shahverdi AR, Rezayat SM, Amini MA, Amani A. ...
  • Sailakshmi G, Mitra T, Chatterjee S, Gnanamani A. Engineering Chitosan ...
  • Alsarra IA, Neau SH, Howard MA. Effects of preparative parameters ...
  • Gazori T, Khoshayand MR, Azizi E, Yazdizade P, Nomani A, ...
  • Motwani SK, Chopra S, Talegaonkar S, Kohli K, Ahmad FJ, ...
  • Vandenberg GW, Drolet C, Scott SL, de la Noue J. ...
  • Wu Y, Yang W, Wang C, Hu J, Fu S. ...
  • Kouchak M, Avadi M, Abbaspour M, Jahangiri A, Boldaji SK. ...
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