Slow Repetitive Nerve Stimulation in Patients with Acute Organophosphorus Poisoning after Clinical Recovery
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 232
فایل این مقاله در 5 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_PJMT-2-1_004
تاریخ نمایه سازی: 23 مهر 1398
چکیده مقاله:
Background: Prolonged inhibition of acetylcholine esterase may lead to the intermediate syndrome. Neuromuscular junction (NMJ) dysfunction has been shown with repetitive nerve stimulation (RNS). Subclinical NMJ dysfunction may also occur. We aimed to examine the NMJ function following acute organophosphorus (OP) poisoning by using exercise modified slow RNS. Methods: A cohort study was conducted with matched controls. Patients with acute OP poisoning were enrolled. NMJ function, muscle power and tendon reflexes were assessed at discharge and six weeks after exposure. NMJ function was assessed with exercise modified supramaximal slow RNS of the median nerve. Results: There were 68 patients and 71 controls. Mean (SD) age of patients and controls were 32 (12) and 33 (12) years. In some particular amplitude, the decrement response was statistically significant. They were decrement response at rest, at fourth amplitude (95% CI: -0.2 to -2.7) and two minutes post-exercise at fourth and fifth amplitudes (95% CI: -0.8 to -5, -1 to -5 respectively) in the second assessment compared to controls, decrement response at rest at fourth and fifth amplitudes (95% CI: -4 to -0.5, -3.9 to -0.01 respectively) and two minutes post-exercise at fourth amplitude (95% CI: -5 to -0.8) in the second assessment compared to the first assessment. Patients in the first assessment and controls showed more than 8% decrement response either to the second, fourth or fifth stimuli in seven and five occasions respectively. Conclusion: There was no significant neuromuscular junction dysfunction assessed by exercise modified slow repetitive stimulation following acute exposure to OP. Since, NMJ dysfunctions are likely to occur following OP poisoning, other electrodiagnostic modalities such as SF-EMG are probably more efficient to assess these abnormalities.
کلیدواژه ها:
Organophosphorus compounds ، Poisoning ، Electrodiagnosis ، Neuromuscular Junction ، Exercise Modified Slow Repetitive Stimulation
نویسندگان
Sudheera Jayasinghe
Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Sri Lanka. Asian Clinical Toxicology Research Collaboration, Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka. Clinical Neuroscience Center,
Kithsiri Pathirana
Clinical Neuroscience Center, Department of Medicine, Faculty of Medicine, University of Ruhuna, Sri lanka.
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :