Association of cytogenetics and immunophenotype in prognosis of children with acute lymphoblastic leukemia: Literature Review

سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 310

فایل این مقاله در 5 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_RCM-1-1_001

تاریخ نمایه سازی: 2 دی 1398

چکیده مقاله:

Acute lymphoblastic leukemia (ALL) is the most common type of neoplastic disorder diagnosed in childhood. It is the cause of one third of all pediatric malignancies. ALL is characterized by the abnormal production and proliferation of immature lymphoblasts in bone marrow (BM). It seems that ALL occurs due to a genetic mutation in DNA structure producing white blood cell (WBC) stem cells. Because ALL is a systemic disease, its primary management is based on chemotherapy.There are important risk factors responsible for the poor prognosis of  ALL in children less than 1 year old and greater than 10 years old, such as: high WBC, mature T cell ,mature B cell, central nervous system (CNS) involvement, DNA index < 1 (hypodiploid), triploidy, tetraploidy, Mixed-Lineage Leukemia (MLL) gene re-arrangement on 11q23, the Philadelphia chromosome t(9;22),  reduction in platelet count, hemoglobin> 10 at diagnosis, no remission at the end of induction therapy and Minimal residual disease at the end of consolidation therapy. Complications might appear during the treatment including tumor lysis syndrome, bleeding, renal failure, sepsis, seizure, thrombosis, etc. Some consequences might identify after a long-term follow-up such as learning impairment, growth retardation, and secondary malignancies. It is estimated that up to 90% of pediatric ALL cases are curable.

نویسندگان

Abdollah Banihashem

Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ali Ghasemi

Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Lueisa Tavasolian

Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • H Ronald Hoffman BF, Philip McGlave, Leslie ES, Sanford JS, ...
  • Conter V, Bartram CR, Valsecchi MG, et al. Molecular response ...
  • Khalid S, Moiz B, Adil SN, et al. Retrospective review ...
  • Braoudaki M, Lambrou GI, Vougas K, et al. Protein biomarkers ...
  • Assumpção JG, Paula FD, Xavier SG, et al. Gene rearrangement ...
  • Kiyokawa N, Iijima K, Tomita O, et al. Significance of ...
  • Vitale A, Guarini A, Ariola C, et al. Absence of ...
  • Zhao Y, Huang H, Wei G. Novel agents and biomarkers ...
  • Niedzielska E, Węcławek-Tompol J, Matkowska-Kocjan A, et al. The influence ...
  • Mazloumi SH, Madhumathi DS, Appaji L, et al. Combined study ...
  • Bhojwani D, Howard SC, Pui CH. High-risk childhood acute lymphoblastic ...
  • Matutes E, Morilla R, Farahat N, et al. Definition of ...
  • McGregor S, McNeer J, Gurbuxani S. Beyond the 2008 World ...
  • Mi JQ, Wang X, Yao Y, et al. Newly diagnosed ...
  • Patkar N, Alex AA, B B, Ahmed R, Abraham A, ...
  • Settin A, Al Haggar M, Al Dosoky T, et al. ...
  • Hilden JM, Dinndorf PA, Meerbaum SO. Analysis of prognostic factors ...
  • Hashemi A, Manochehri MA, Eslami Z, et al. Evaluation of ...
  • Moorman  A, Richards S, Robinson H,  et al. Prognosis of ...
  • نمایش کامل مراجع