Association of TYK2 rs34536443 polymorphism with Susceptibility to Systemic Lupus Erythematous in the Iranian Population

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 368

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شناسه ملی سند علمی:

JR_RHRE-3-4_005

تاریخ نمایه سازی: 1 خرداد 1398

چکیده مقاله:

Systemic lupus erythematous (SLE) is a multifactorial autoimmune disorder which affects many organs and displays various symptoms. Genetic components contribute to the incidence and development of SLE. A rare functional variant within the tyrosine kinase 2 (TYK2) gene (rs34536443) is a common genetic candidate for several autoimmune diseases, including SLE. This case control study was performed to investigate the possible association of TYK2 single nucleotide polymorphism (SNP) with a predisposition for and clinical features of SLE in the Iranian population.Genotyping was conducted on 600 patients with SLE and 600 sex-, age- and ethnicity-matched control subjects from the Iranian population. Patient and control samples were genotyped for one SNP (rs34536443) by applying allelic discrimination real-time PCR.Statistical analysis of the allele distribution revealed no significant association (OR = 0.67, CI: 0.38-1.17, P value = 0.163) between the rs34536443 C allele and susceptibility to SLE. The CC genotype was not detected in either the patients or controls. Moreover, the CG genotypes showed no significant association with the risk of SLE (OR = 0.66, CI: 0.37-1.72, P value = 0.15).These findings suggest that TYK2 rs34536443 is not associated with SLE susceptibility in the Iranian population. Further investigation is required to examine the mechanisms by which polymorphisms in this gene lead to SLE development.

نویسندگان

Seyedeh Tahereh Faezi

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Samaneh Soltani

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Mahmoud Akbarian

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Saeed Aslani

Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

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  • Gregersen PK, Behrens TW. Genetics of autoimmune diseases-disorders of immune ...
  • Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, ...
  • Sigurdsson S, Goring HH, Kristjansdottir G, Milani L, Nordmark G, ...
  • International Consortium for Systemic Lupus Erythematosus G, Harley JB, Alarcon-Riquelme ...
  • Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, ...
  • Cunninghame Graham DS, Manku H, Wagner S, Reid J, Timms ...
  • Ronnblom L, Alm GV. Systemic lupus erythematosus and the type ...
  • Villarino AV, Kanno Y, O’Shea JJ. Mechanisms and consequences of ...
  • Cunninghame Graham DS, Akil M, Vyse TJ. Association of polymorphisms ...
  • Sato K, Shiota M, Fukuda S, Iwamoto E, Machida H, ...
  • Peluso C, Christofolini DM, Goldman CS, Mafra FA, Cavalcanti V, ...
  • Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, ...
  • Lopez-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S, ...
  • Lee YH, Bae SC. Association between TYK2 polymorphisms and susceptibility ...
  • Kang EH, Choi JY, Lee YJ, Lee EY, Lee EB, ...
  • Hellquist A, Jarvinen TM, Koskenmies S, Zucchelli M, Orsmark-Pietras C, ...
  • Jarvinen TM, Hellquist A, Koskenmies S, Einarsdottir E, Koskinen LL, ...
  • Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, Hashimoto H, ...
  • Cunninghame Graham DS, Morris DL, Bhangale TR, Criswell LA, Syvanen ...
  • Lee YH, Choi SJ, Ji JD, Song GG. Associations between ...
  • Tang L, Wan P, Wang Y, Pan J, Wang Y, ...
  • Tao JH, Zou YF, Feng XL, Li J, Wang F, ...
  • Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, ...
  • Zervou MI, Dimopoulou DG, Eliopoulos E, Trachana M, Pratsidou-Gkertsi P, ...
  • Dyment DA, Cader MZ, Chao MJ, Lincoln MR, Morrison KM, ...
  • Eyre S, Bowes J, Diogo D, Lee A, Barton A, ...
  • Peluso C, Christofolini DM, Goldman CS, Mafra FA, Cavalcanti V, ...
  • Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, ...
  • Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Ronnblom L, ...
  • Hochberg MC. Updating the American College of Rheumatology revised criteria ...
  • Koshy L, Anju AL, Harikrishnan S, Kutty VR, Jissa VT, ...
  • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a ...
  • Shi YY, He L. SHEsis, a powerful software platform for ...
  • Kyogoku C, Tsuchiya N. A compass that points to lupus: ...
  • Chasset F, Arnaud L. Targeting interferons and their pathways in ...
  • Ronnblom L, Alm GV, Eloranta ML. The type I interferon ...
  • Niewold TB, Clark DN, Salloum R, Poole BD. Interferon alpha ...
  • Tokumasa N, Suto A, Kagami S-i, Furuta S, Hirose K, ...
  • Richter MF, Dumenil G, Uze G, Fellous M, Pellegrini S. ...
  • Platanias LC, Fish EN. Signaling pathways activated by interferons. Exp ...
  • Suarez-Gestal M, Calaza M, Endreffy E, Pullmann R, Ordi-Ros J, ...
  • Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, ...
  • Genetic Analysis of Psoriasis C, the Wellcome Trust Case Control ...
  • Diogo D, Bastarache L, Liao KP, Graham RR, Fulton RS, ...
  • Zervou MI, Dimopoulou DG, Eliopoulos E, Trachana M, Pratsidou Gkertsi ...
  • Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, ...
  • Hinks A, Cobb J, Sudman M, Eyre S, Martin P, ...
  • Tao J-H, Zou Y-F, Feng X-L, Li J, Wang F, ...
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