Study of the Expression of miR-4270 in Plasma of Patients with Breast Invasive Ductal Carcinoma

سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 366

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شناسه ملی سند علمی:

JR_SGR-4-2_002

تاریخ نمایه سازی: 3 دی 1398

چکیده مقاله:

Detection of tumor-specific microRNAs (miRs) in the blood of cancer patients may provide a unique and valuable biomarker for diagnosis and prognosis. The aim of this study was to investigate whether plasma levels of microRNA-4270 could serve as a potential marker for breast invasive ductal carcinoma. A total of 40 breast cancer patients and 28 controls were recruited in this study. Total RNA was extracted from plasma samples andmiR-4270 expression was evaluated by real-time polymerase chain reaction (PCR). The correlation between miR-4270 expression and clinicopathological characteristics were also studied. Our data showed that plasma miR-4270 is significantly up-regulated in patients compared to control group (P-value=0.00). In addition, data analysis illustrated a correlation between low plasma levels of miR-4270 and larger tumor size, lymph node metastasis and higher stages of malignancy (P-value > 0.05). The area under the curve of the ROC revealed thatmiR-4270 expression was not able to distinguish between tumor plasmas and nontumoral specimens. Current work shows preliminary data on the expression profile of-4270 in plasma of breast cancer patients. However, further studies are required to fully elucidate the role of circulating mix-4270 in breast ductal carcinoma.

نویسندگان

Faezeh Aminisepehr

Department of Biological Sciences, School of Natural Sciences, University of Tabriz

Esmaeil Babaei

Department of Biological Sciences, School of Natural Sciences, University of Tabriz

Mohammad Ali Hosseinpour Feizi

Department of Biological Sciences, School of Natural Sciences, University of Tabriz

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