Effects of Zoledronic Acid and Vitamin E on Surgical– Induced Osteonecrosis of the Femoral Head in Rabbit
محل انتشار: مجله استخوان و جراحی عمومی، دوره: 6، شماره: 6
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 275
فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_TABO-6-6_011
تاریخ نمایه سازی: 18 تیر 1398
چکیده مقاله:
Background: Femoral head osteonecrosis is a progressive disease with disabling outcomes in hip joint if not treated.This study was designed to compare the effects of zoledronic acid plus vitamin E versus zoledronic acid alone insurgical induced femoral head osteonecrosis in rabbits.Methods: 26 Japanese white adult normal male rabbits at 28-32 weeks old were undertaken surgical femoraldislocation to devastate the femoral neck vessels; the femoral neck vessels were ligated and the hip was relocated.Next, the first 10 rabbits received zoledronic acid injections at 1st and the 4th weeks; the second group (10 rabbits)received zoledronic acid injections at 1st and the 4th week along with daily oral vitamin E for 12 weeks; and thethird group was considered as non-treated control group. Radiographic and postmortem pathological assessmentsincluding the Ficat classification, epiphyseal quotient (EQ), new bone formation, and residual necrotic bone (RNB)were performed and compared after week 12.Results: A significant difference was found between the combination therapy group and the control group in Ficatclassification at 12th weeks (P=0.048), but, the difference between monotherapy and combination therapy groups at12th weeks was nonsignificant (P=0.37). Also, both treated groups had significant difference with the control group forRNB (P=0.015). There were no significant differences between the three groups for Ficat classification at the 6th week(P=0.65); EQ at 6th (P=0.59) and 12th week (P=0.64); and NBF (P=0.55).Conclusion: Although zoledronic acid therapy along with vitamin E could improve some radiologic and pathologicalindices related to femoral head osteonecrosis, vitamin E showed a relative impact.Level of evidence: I
کلیدواژه ها:
نویسندگان
Kaveh Gharanizadeh
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
Sina Aminizadeh
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
Nima Molavi
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
Amir Darbandi
Rajaie Cardiovascular, Medical and Research Centre, Iran University of Medical Sciences (IUMS), Tehran, Iran