Introduction: Coronary heart disease is one of the main causes of premature mortality and morbidity in most societies today, and with regard to the prevalence and increasing trend of coronary artery disease and known complications and anonymity Other important causes of coronary artery disease, including inflammatory factors and inadequate reports, were the correlation between
IgG4 as an inflammatory factor in the severity of coronary artery disease and the lack of reporting on its experience in the country in order to determine the serum
IgG4 level and the severity of coronary artery disease This research was carried out at Bu-Ali Hospital in Tehran in 2017-18Materials and methods: This research is a cross-sectional study. 44 woman patients, 23 patients with
coronary artery stenosis and 21 patients with normal coronary artery who were candidates for angiography ,gradually entered into our study after applying inclusion and exclusion criteria. Prior to performing the angiography, blood samples were taken from patients in order to determine the level of
IgG4 and other blood parameters. After collecting the results of angiography and blood samples and demographic information of patients with a researcher-made questionnaire, the data were analyzed by SPSS version 24 software with non parametric method and a meaningful level was taken as P value <0.005 .Results:This study was performed on 44 woman patient candidates for angiography, 23 patients with
coronary artery stenosis and 21 patients with normal coronary artery.The mean age of patients was 62.2 ± 1.6 years. The mean BMI in all 2 groups was 27.63 ± 0.63. The LAD vessel with 37.1% had the highest frequency of coronary atherosclerosis afterwards RCA and LCX vessels with 20.2% and 13.5% had the highest frequency of coronary atherosclerosis . There was no significant relationship between age, body mass index, depression status with
IgG4 and coronary stenosis.There was a significant correlation between serum
IgG4 level and coronary stenosis , and
IgG4 levels were lower in patients with normal coronary artery than in other group .Conclusion: According to the findings of this study, serum
IgG4 levels were significantly higher in the group with
coronary artery stenosis than in the without stenosis group. Therefore, we can use serum
IgG4 as a diagnostic and prognostic factor in coronary artery disease.