Laparoscopy in Ovarian Cancer for selection Neoadjuvant Chemotherapy vs. Primary Cytoreductive Surgery

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 430

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شناسه ملی سند علمی:

LAMOGMED03_115

تاریخ نمایه سازی: 21 بهمن 1397

چکیده مقاله:

Objective: Laparoscopy has also been reported on for staging in early ovarian cancer. The aim of this study is to evaluate the results of laparascopy for selection of neoadjuvant chemotherapy (NACT) and the impact of interval debulking surgery (IDS) on clinical outcomes of patients with advanced-stage ovarian cancer.Methods: We performed a retrospective analysis on 92 patients with advanced ovarian cancer admitted to ValiAsr Gynecologic oncology departments during 1996–2012. Comparison was made with results of laparscopy for selection of patients for neoadjuvant chemotherapy of 24 patients with unresectable advanced epithelial ovarian cancer treated with platinum- based NACT followed by IDS and clinical outcomes of 68 consecutive stage III and IV ovarian cancer patients treated with primary cytoreduction followed by platinum-based adjuvant chemotherapy. Results: Primary cytoreductive surgery caused longer survival compared to neoadjuvant chemotherapy. Patients who underwent optimal interval debulking surgery (IDS) had a better progression free survival (PFS) (p=0.002) and overall survival (p=0.03)than those who did not. There were not significant differences between the two groups in complications of surgery. Conclusion:laparascopy for selection of NACT followed by successful IDS can lead to high survival percentage in patients with chemoresponsive advanced ovarian cancer; although the result is more effective in those with optimal primary cytoreduction, we still got the same results with those with suboptimal primary cytoreduction.

نویسندگان

Mojgan Karimi-Zarchi

Prof,Gynecolohist Oncologist,Iran University of Medical Science,Tehran,Iran