COMPARISON OF PROBIOTIC THERAPEUTIC EFFECTS IN ERADICATION OF HELICOBACTER PYLORI INFECTION

Background and Aim:Helicobacter pylori (H-pylori) antibiotic resistance is a growing problem which needs an alternative treatment with acceptable eradication effect. Several studies have been done in relation to effect of probiotics in different infectious diseases, therefore the aim of this study is evaluating the effect of adding probiotic to the Helicobacter pylori’s standard eradication regimen.Methods: In this clinical trial, we studied 120 patients with H. pylori infection in two groups (60 subjects in each probiotic and control groups). Both groups were treated with quadruple regimen of omeprazole, bismuth, clarithromycin, and amoxicillin for two weeks. In addition, the intervention group, received protexin (restore). After 4 weeks of treatment, outcome and eradication success rates were measured in both groups.Results: Eradication success rate based on pathological and carbon-14 breath test assessment was significantly higher in the intervention group as compared to control group (p < 0.05). Moreover, the complication rates did not differ between both groups. (P> 0.05(Conclusion:Adding probiotic to the Helicobacter pylori’s standard treatment regimen will increase eradication success rate without causing significant complications.

کلیدواژه ها:

Helicobacter pylori ، Probiotic ، Eradication