ANTIFUNGAL EFFECT OF ALLIUM CEPA ETHANOLIC EXTRACT AGAINST TRICHOPYTON RUBRUM

Background and Aim:Dermatophytosis is one of the most common superficial fungal infections worldwide. Trichophyton rubrum is one of the most common of dermatophytes that caused variety of clinical forms. Due to the recurrence of recurrent infections due to the resistance of the organism to the drug and the side effects of prolonged use of anti-inflammatory drugs, including long-term therapeutic strategies the aim of this study was to investigate the effect of ethanolic extract of Alium cepa (AEC) on T.rubrum growth.Methods:The inhibitory effect of (ACE) extract against T. rubrum was assessed by broth microdilution (CLSI, M-38) methods in comparing with terbinafine.Results:The results showed that the minimum inhibitory concentration (MIC) of ACE and terbinafin for fungi growth was 1.46 and 1µg/ml and MIC 50 for these compounds was 0.73and 0.5 µg/m l, respectively.Conclusion:The results of this study showed that ACE is an effective factor that inhibit Thrichophyton rubrum growth and can be considered as a target for antifungal design methodology.

کلیدواژه ها:

Allium cepa ، Trichophyton rubrum ، MIC ، Antifungal effect