SYNTHESIS AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES DERIVATIVES CONTAINING HALOGEN

Background and Aim:Oxadiazoles are the heterocyclic compounds containing one oxygen and two nitrogen atoms in a five membered ring possessing a diversity of useful biological effects. Oxadiazole is considered to be resultant from furan by replacement of two methane (–CH=) groups by two pyridine type nitrogen atoms (–N=). Several methods have been reported in the literature for the synthesis of 1,3,4-oxadiazoles. The aim of this study was to evaluate the antibacterial properties of oxadiazole synthesized derivatives and compare it with common antibacterial drugs on bacterial pathogens.Methods:In this study in a singleprocess reaction of N- isocyanimino triphenyiphosphorane, carboxylic acid derivatives and 2-pyridinecarbalhyde in acetonitrile solvent, new derivatives of Oxadiazole were attained. The structures of synthesis compounds were surveyed and established by the use of IR, H-NMR and C-NMR spectrometer. The synthesized compounds were tested for their antimicrobial activity against Entrococcus faecalis PTCC 1788 and Proteus vulgaris PTCC 1861 by disc diffusion method and Minimal Inhibitory Concentration (MIC) and determination of Minimal Bactericidal Concentration (MBC).Results:The results that show all the synthesized compounds had antibacterial activity against gram positive bacteria, but they did not have that much influence on gram negative bacteria.Conclusion: This is important that the synthesis of Oxadiazole compounds has antibacterial nature which is a single-process reaction and it was accomplished with high efficiency and in a very short time.

کلیدواژه ها:

Antibacterial ، Oxadiazole ، Enterococci ، Proteus