PROPIONIC ACID: METHODS OF PRODUCTION AND CURRENT STATE

Background and Aim:Bio-production of propionic acid by Propionibacterium has been received considerable attention, however, there are some drawbacks and limitations for application, thereby strategies are proposed in order to increase production yield.Methods:This review contributes to a comprehensive overview of important biotechnological aspects of propionic acid (PA) production as a common ingredient in food and biotechnology industries. Major available PA production processes, focusing mostly on biological production, were discussed.Results:Important PA producers, principally Propionibacterium as the most prevalent one, and a wide range of reported straightforward and complex growth/production mediums were summarized. Furthermore, bioprocess variables, which could influence the production yield are described. Also, possible methods of extraction and analysis of PA as well as the introductions of different strategies in order to overcome limitations of competitive microbial production from the economical point of view are proposed.Conclusion:Appropriate pre-adaptation of the microorganism and application of metabolically engineered mutant may lead to increased production yield of biomass and acid. The most significant factors influencing the production of PA in submerged fermentation are temperature and pH control that directly influence the high yields.

کلیدواژه ها:

Fermantation ، Glycerol ، Propionibacterium ، Propionic acid ، Propionic acid production ، Propionic acid productivity