EVALUATION OF THE SYNERGISTIC EFFECTS OF THE ALCOHOLIC EXTRACT OF STACHYS BYZANTINA IN COMPARISON WITH GENTAMYCIN, ERYTHROMYCIN AND PENICILLIN ANTIBIOTICS

Background and Aim:Due to the increasing of microbial resistance strains to antibiotic, identify and introduce the antimicrobial substances with plant origin are important. Plants of Lamiaceae family with antimicrobial property are used for the treatment of infectious diseases.Methods:This experimental study was conducted to investigate the synergistic effects of the alcoholic extract of Stachys byzantina on standard strains and in comparison with three antibiotics Gentamycin, Erythromycin and Penicillin. Phytochemical experiments were also carried out.Results:The results of this study showed that the alcoholic extract of the Stachys byzantina only has an antagonistic effect on penicillin antibiotic activity against Staphylococcus epidermidis.And does not affect on the performance of gentamicin against Staphylococcus aureus, but it increases the sensitivity of Pseudomonas aeruginosa to penicillin, gentamicin and erythromycin.Phytochemical results revealed that the presence of alkaloid, carbohydrate, tannin, terpenoid, steroid, saponin and flavonoid.Conclusion:It seems that the extract of Stachys byzantina has an inhibitory effect, both alone and in combination with other antimicrobial agents and improves the performance of some of antibiotics.

کلیدواژه ها:

Alcoholic extract ، Stachys byzantina ، synergistic effect ، Phytochemical compound ، antimicrobial activity