Systematic Study for Synthesis of La3+/α-Al2O3 Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains

In this study for the first time, new nanoparticles of the La3+/α-Al2O3 were synthesized with the ultrasonic-assisted hydrothermal method in the presence of the honey as an eco-friendly and natural reagent. The as-synthesized La3+/α-Al2O3 nanoparticles were characterized using scanning electron microscopy (SEM), transition electron microscopy (TEM), X-ray diffraction spectroscopy (XRD), energy dispersive X-ray (EDX), UV–visible spectroscopy, and Fourier transform infrared spectroscopy (FTIR) techniques. In this work, we report optimum conditions for the synthesis of La3+/α-Al2O3 nanoparticles as novel material and as the candidate for antibacterial activity in antibacterial drugs. The XRD and SEM micrograph results demonstrate the formation of pure La3+/α-Al2O3 nanoparticles with a sphere like in the size range of 30–80 nm. The synthesis parameters were systematically examined using analysis of variance (ANOVA) through 2k−1 factorial design and the factors were an assay for product optimization. Results show La3+/α-Al2O3 nanoparticles capable considerably inhibited the growth of antibiotic-resistant Escherichia coli, pseudomonas aeruginosa and Serratia marcescens as gram negative bacteria and Bacillus subtilis and Micrococcus luteus as gram positive bacteria between 64 up to 32 μg/ml. The antibacterial activity was carried out against 7 Gram negative and Gram-positive bacteria using agar well diffusion assay and minimum inhibitory concentration (MIC) was determined.

کلیدواژه ها:

Ultrasound assisted hydrothermal method ، La3+/α-Al2O3 NPs ، Nanocomposites ، Antibacterial activity