The Prevalence of Pseudomonas aeruginosa isolates recovered from the gastric mucosa of dyspeptic Patients admitted to the Mehrad Hospital, Tehran, Iran

Introduction: The gastric acidic condition inhibits the rapid growth of many common digested bacteria. However, our understanding about current composition of gastric biota is limited. Helicobacter pylori is the regular colonizer of human stomach but we are unaware of other bacteria. Pseudomonas aeruginosa is one of bacteria listed as potential colonizers of the stomach while we have no data about its exact prevalence in this microniche. Materials and methods: A total of 25 biopsy samples obtained from dyspeptic patient were examined to determine the prevalence of P. aeruginosa using specific PCR method. Our criteria to choose this the samples was being infected with H. pylori. Results: Overall, 16 out of 25 dyspeptic samples were H. pylori positive (P value=0.005), 15 out of 16 H. pylori positive were P. aeruginosa positive. A total 9 non-dyspeptic patients obtained 7 P. aeruginosa positive samples. Conclusion: Pseudomonas aeruginosa seems a critical member of bacteria colonizing the human stomach when H. pylori colonization. We need more studies to identify the exact association between acid suppressive drugs and overgrowth by such opportunist bacteria such as P. aeruginosa in dyspeptic patients.

کلیدواژه ها:

Pseudomonas aeruginosa ، PCR method ، Dyspeptic Patients ، endoscopy surgery