Synthesis of a new bis thi aza crown compound
محل انتشار: همایش منطقه ای شیمی
سال انتشار: 1389
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 213
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شناسه ملی سند علمی:
MIAUCHEMISTRY01_132
تاریخ نمایه سازی: 18 اسفند 1397
چکیده مقاله:
Macrocyclic diamides and corresponding aza crown compounds and dimers form have gained a great deal of attention due to their wide applications in nano technology, waste water treatment, nuclear energy, chemistry, biology, medical, anti HIV, anti bacterial, anti biotic, industrial uses [1,2]. In this research work we wish to report synthesis new bis thia aza crown as carrier nano drugs. In this research work bis phenole (1) gained by reaction p-Cresol with sulfur dichloride in 45% yield. Treatment of bisphenole (1) with methyl chloroacetate in the presence of K2CO3 and KI at refluxed in dry acetone gave dimethyl ester (2) in 98% yield. Macrocyclic diamide (3) in 70% yield was prepared by diamidation of diester (2) with diethylentriamine, and then purified with recrystaliztion from methanol. Bis crown ether was synthesized by reaction of macrocyle (3) and E-pent-2-enedioyl dichloride in 60% yield. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR and elemental analysis.
نویسندگان
S. Alami
Member of young research club Islamic Azad university of Tabriz- Islamic Azad University of Tabriz Branc h, Tabriz, Iran
S. Bavili Tabrizi
Islamic Azad University of Tabriz Branc h, Tabriz, Iran
N. Vahid Mahdinia
Islamic Azad University of Tabriz Branc h, Tabriz, Iran